The 79-year-old pioneering black actor could face the rest of his life in prison if convicted on three counts of aggravated indecent assault for allegedly drugging and molesting a woman at his home in 2004.
Trial began June 5, and the jury started their deliberations Monday night.
Jurors appeared exhausted and spent when they chose to call it quits late Tuesday after about 16 hours of deliberations.
Earlier, jurors asked to rehear a part of Constand's testimony about the night of the alleged assault. 12 witnesses were called during a week, but there was no forensic evidence.
During a lunch break Tuesday, Wyatt appeared on the courthouse steps to tell a crowd of reporters and cameras about what a defense witness would have said in court - damaging to the credibility of Constand - had O'Neill not barred her testimony as hearsay. The jury has wrapped up a second day of deliberations without reaching a verdict.
In one of the biggest U.S. celebrity trials in years, a guilty verdict could see the judge sentence Cosby up to 10 years in prison and a $25,000 fine on each count.
But the allegations lodged by 44-year-old Canadian Andrea Constand about an encounter in January 2004 are the only criminal case brought against him.
Cosby said he gave Constand three half-tablets of Benadryl, an over-the-counter cold and allergy medicine, to help her relax.
"My interactions with him, he's been in good spirits, " Pulliam said. The comedian acknowledged groping Andrea Constand after giving her pills.
"Put them down, they're your friends". Cosby said he never took the powerful sedative, preferring to keep it on hand for social situations. "You've sent word: You're exhausted", said Judge Steven O'Neill, dismissing the panel until this morning.
She became incapacitated and felt "frozen" and told him so, she testified. That it couldn't have been assault if she had an orgasm.
Mr. Cosby said Ms. Constand often wasn't thinking clearly and he believed she had a learning disability or Attention Deficit Disorder.
"Sexual assault is nothing I take lightly or that I condone in any way shape or form, but he is still a father, someone's husband", she said.
Cosby lowered and shook his head in the courtroom as she spoke.
Constand's mother wiped away tears at times as the interview was read.
"It won't change the love because when you have family, people falter, people make mistakes, things happen, but in no way is that condoning sexual assault", she continued. Cosby's defense team argues that the two were in a relationship at the time and it was consensual.
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But she said the hotel room meeting was not romantic, and explained that she made those phone calls in her job responsibility at Temple.