These penalties were imposed after the NCAA investigated for 13 months into Louisville basketball staffer Andre McGee allegedly paying women for stripteases and sex with players and recruits.
This appeal comes almost two months after the NCAA Committee on Infractions made its official ruling against Louisville, which said the men's basketball program must vacate 123 wins, the 2012 Final Four appearance and the 2013 national championship.
From here, the NCAA's Committe on Infractions has 30 days to issue a response to Louisville's appeal, and the two sides will exchange more documents this fall before the appeals committee conducts a hearing on the matter.
From there, U of L blasted away at penalties handed down by the NCAA's committee on infractions, namely the vacating of several seasons worth of victories - including two Final Four appearances and the 2013 NCAA championship - and the forfeiture of NCAA tournament money earned during those seasons.
If Louisville's penalties are upheld, the school noted that it would mark the first time a Division I men's basketball title would be vacated. The Hall of Fame coach called the NCAA penalties "unjust and over the top in its severity" when they were announced on June 15.
"The university fully agrees with the COI that McGee committed egregious misconduct", the summary of Louisville's appeal said.
The COI was especially critical of Pitino and said he should have known about McGee's activities with Powell, whose book, "Breaking Cardinal Rules: Basketball and the Escort Queen" alleged that McGee paid her $10,000 for 22 shows at the Cardinals' dormitory from 2010-14.
Louisville's appeal also said the COI imposed "a more draconian set of penalties" than warranted and said it ignored corrective measures.