Mr Jackson also released a Northwestern Medicine letter saying he was diagnosed in 2015 and has since sought outpatient care.
Jackson was at first reluctant to visit the doctor, but as his symptoms became more and more disruptive over the past three years, he finally "acquiesced".
Parkison's disease is a neurodegenerative disorder that results from loss of cells in various parts of the brain that control movement. Its symptoms include muscle rigidity, tremors and changes in speech and gait.
"For 50 years that I've known Jesse Jackson, he has been an absolute voice of progressive thought, progressive development, representing the views and needs of the downtrodden".
Most recently, the 76-year-old has fought through the Rainbow Push Coalition for social change and a safe society in Chicago, which has been labelled as "murder capital of America".
Jackson goes on to describe the pain that has come with understanding the realities of the disease, and the passion he feels for slowing the disease's progression, via physical therapy.
He received the Presidential Medal of Freedom from President Bill Clinton.
He noted that the same disease "bested my father".
A spokesman said Jackson declined to comment further.
United States civil rights campaigner Jesse Jackson has revealed he is suffering from Parkinson's disease.
Parkinson's runs in Jackson's family.
He also said he would use his diagnosis as an opportunity to educate others about the neurological illness, with a largely unknown cause and no cure, that afflicts seven to 10 million people worldwide.
"I will need your prayers and graceful understanding as I undertake this new challenge", the statement said.
Chicago Tribune reporter John Byrne contributed.