Mayor of London Sadiq Khan met Pakistani business leaders and students at Habib University on Friday, one day after he arrived in the country.
Senior journalists were also there to cover the event and hear the London Mayor speak.
Addressing the media after his visit to Quaid-e-Azam Muhammad Ali Jinnah's mausoleum, Sadiq said, "I feel honoured to be in Karachi, I am thankful to Pakistan for its hospitality".
Sadiq Khan is leading a trade mission under the theme "London Is Open" to both India and Pakistan and is flanked by a 16-member delegation.
Sadiq, who won London's mayoral elections in May past year after defeating multi-billionaire Tory candidate Zac Goldsmith, arrived in Pakistan on Wednesday for a three-day official visit.
He invited Pakistanis to invest in London and spend their holidays in the city as well.
Chief Minister Punjab Shehbaz Sharif, who would be hosting a dinner in the honour of Sadiq Khan, took to Twitter and welcomed the visiting dignitary.