Mohamed Elneny could also start in midfield if Wenger opts to rest one of Jack Wilshere, Aaron Ramsey or Granit Xhaka. Pierre-Emerick Aubameyang will return to the starting eleven, and it will be interesting to see if Alexandre Lacazette starts on the bench.
Arsenal host Southampton on Sunday afternoon as the Premier League rumbles on.
Southampton have a fully-fit squad to choose from after Steven Davis recovered from a hamstring problem.
He won his first match as manager of the Saints by beating Wigan in the FA Cup quarter-final, but the 3-0 defeat against the Hammers once again emphasised how hard it will be to secure his side's top-flight status for another season.
However, having failed to secure victory in four of their last five encounters, they have been tagged as underdogs for this game at the odds of (5.70) with the same betting firm.
Southampton will be outright second favourites to gain anything from his fixture, especially following Arsenal's impressive midweek feat in the Europa League over CSKA Moscow, but it could be a season-defining match for the Saints.
Charlie Austin is the club's top scorer with six goals to his name so far this season. The last time they won three in a row by a margin of at least three goals was in October 2015.
Arsenal signed Borussia Dortmund striker Pierre-Emerick Aubameyang in a club record £56m deal in the January transfer window to bolster Arsene Wenger's attacking options for the remainder of the season. The Saints are in desperate need of points; they are two behind 17th place with a game in hand and are in real danger of being relegated.
Arsenal's last seven league games at the Emirates have ended with more than 2.5 goals.