Thousands of Palestinians were injured on Monday, and local authorities say that at least 58 were killed by Israeli forces along the Gaza border.
Earlier on Wednesday, Pope Francis expressed grave concern over the tensions in the Holy Land and the Middle East, which have reignited in recent days following the relocation of the USA embassy to Jerusalem.
Pope Francis passes by a banner of Philippines' believers during a weekly general audience at St Peter's square on May 16, 2018 in Vatican.
Pope Francis asked all parties involved in the conflict and the whole worldwide community to renew their promise so that dialogue, justice and peace takes precedence.
"I express my great sorrow for the dead and wounded and with prayer and affection I am close to all who suffer", he said speaking in Italian.
Calling for "dialogue, justice and peace", Francis said violence "has never led to peace. War incites war, violence incites violence".
Francis has on several occasions expressed support for a two-state solution to the Israeli-Palestinian conflict, indirectly criticizing US President Donald Trump's decision to recognize Israel's claim to Jerusalem as its capital. This is what he said when greeting a group of retired soldiers from World War II.
It comes after the Anglican bishop of Southwark Christopher Chessun, who regularly travels to Gaza, said he is "horrified" at the use of live fire by Israeli forces which led to 60 deaths on the Strip on Monday.
He said: "When I read this, I think about myself, because I'm a bishop and I'll have to take my leave". The Anglican Church is committed to serve the people of Gaza through the extraordinary work of the hospitals I was able to visit there past year'. At the end of the Audience he sent out this cry for peace in the Holy Land.