Nadal endured a nervy conclusion to the final, however, when he needed treatment in the fourth game of the final set for a finger injury before sealing victory on a fifth match point when Thiem fired a backhand long.
Thiem had spoken prior to play about knowing how to beat the former Wimbledon champion, yet he was never able to show his best in Paris on Sunday.
Whilst the prestige of winning yet another major is recognition enough for the Manacor born star, he will also take home the record prize pot of 2.2 million euros.
But against Thiem, there was nothing wrong with Nadal's start.
Still, Nadal was able to complete the job on court Philippe-Chatrier.
Thiem defeated Nadal in Rome past year and was also victorious in the duo's latest match at the Madrid Open in May. Nadal -5.5 games is available on the Exchange at [1.68] and given the fact that Nadal has tended to dominate Thiem on non-quick clay, this should be a very likely outcome if Nadal wins the final.
Thiem used to hike through the Alps in his homeland as part of his training, but the 24-year-old had an even bigger mountain to climb now. Thiem makes his second double fault in the game. Serving at less than 50%, Nadal got plenty of looks at second serves.
The match turned at 5-4 when, on the first point, Thiem missed a simple forehand volley. The Austrian has improved on the return serves here to equalise the game. He removed the tape from his left wrist - the Mallorcan suffered a wrist injury that ruled him out in the first week of the 2016 edition - and the trainer came out again at 3-2.
The number of Masters 1000 titles won by Nadal, the most by a single player since the series began in 1990.