Rashford has started two games for United this season and will miss the next three - starting with Saturday's away Premier League fixture at Watford - after being sent off in the match against Burnley.
When he's available again after his ban, expect to see the 20-year-old Rashford mostly sitting on the bench and making frequent second-half cameos out on one of the wings. They play a lot of games so he will get his opportunity.
"Yes he is (a special talent)", Southgate said of Rashford after seeing him score the only goal in Tuesday's friendly win over Switzerland.
He scored the victor for England against Switzerland on Tuesday night just three days after he scored the opening goal in the UEFA Nations League defeat by Spain.
The issue, however, with Rashford, is not that he isn't playing at all - he evidently is - but it is his position.
Rashford subsequently went to Euro 2016 as England's boy wonder but only played a cameo role in that tournament and was then largely a substitute at this summer's World Cup.
"I don't know [if he will play]", said Mourinho. "He will be a top player".
"Everybody's getting frustrated as he's not playing much, but he is playing for England". Starts on the wing might be scarce, too.
Phil Thompson thinks Marcus Rashford's lack of game time at Manchester United is because of Jose Mourinho's lack of trust in the England striker. He doesn't look at home on the right wing.
"Speaking about Marcus, I think I can expect that Sunday I'm going to be highly criticised for not playing him tomorrow, because some of the boys are really obsessed with me and some of them have a problem with some compulsive lies", he told a press conference.
"For Marcus Rashford, there will come the time when he has to really think about his career and move on". "His performances with England, of course I'm happy, he played well, competed well, he scored and especially in a period where he comes with some sadness after his suspension it was very good that he did that". There's no outward sign of any resentment from Rashford, but will he continue to be content being a so-called "super-sub"? "There is huge competition for places at his club so you can understand that".
"In the 2016/17 season, Marcus Rashford played 32 Premier League matches, 11 Europa League matches, including the final, three FA Cup matches, six League Cup matches including the final and the Community Shield".
Rashford is still raw - his final ball can be poor and his finishing sometimes lets him down - and he makes mistakes, but he is clearly a player for the big occasion.