Doctors Announce First Ever Baby Born From Uterus Transplanted From Dead Body

Postado Dezembro 07, 2018

A Brazilian woman was the first to give birth after receiving a womb transplant from a deceased donor, Reuters reported.

The 32-year-old patient suffered from a rare genetic disorder called Mayer-Rokitansky-Küster-Hauser syndrome (MRKH), which caused her uterus not to develop.

In this case, reported in The Lancet the womb donor was a mother of three in her mid-40s who died from bleeding on the brain.

The womb transplant, lasting over 10 hours, took place in Sao Paolo in Brazil in September 2016. They cite women with inoperable fibroids, or abnormal uterine growths, those who have experienced embryo implantation failure and those who have received pelvic radiation as categories of women who may be able to benefit from uterus transplantation in the future.

Her baby girl was born via caesarean section at 35 weeks and three days, weighing 2.5kg (about 6lbs) and the transplanted uterus was removed during the caesarean section and showed no anomalies.

Since live uterus donors are a limitation, the report shows that uterus transplants from deceased donors are feasible and may open access for all women with uterine problems, without the need for live donors, as is the practice now.

It is hoped that this, the first ever uterine transplant involving a deceased donor and the first uterine transplantation in Latin America, could enable more women struggling with fertility issues to undergo treatment without having to wait for a live donor.

The first childbirth following a uterus transplant occurred in 2013 in Sweden, where a total of eight children have been born thanks to transplants from live donors.

Uterine transplants from deceased donors have been attempted previously, but until last December no recipient had carried a child to term. With a deceased donor, things are a little more rushed and the timing might not be ideal, O'Neill notes, but surgeons can take more tissue from the vagina and blood vessel network than is possible with a living donor.

"The use of deceased donors could greatly broaden access to this treatment, and our results provide proof-of-concept for a new option for women with uterine infertility", Ejzenberg said in a journal news release.

"It enables use of a much wider potential donor population, applies lower costs and avoids live donors' surgical risks", Saso stated.

Person involved with the case say that the new findings show that a uterus transplanted from deceased donors is feasible and opens access to women with uterine infertility without needing to have a live donor.

But Dr. Tullius said surrogacy comes with its own challenges, from compensation to the ethics of asking a woman to undergo the rigours of pregnancy.

At the age of seven months, the baby continued to breastfeed and weighed 15lbs and 14oz (7.2 kilos). Two more women in his program are awaiting suitable donors.

But the 10 previous transplants from a dead donor have failed or resulted in miscarriage.

The world's first baby has been born via a uterus transplanted from a dead donor.

These are still early days for uterine transplants, says Kate O'Neill, co-lead investigator for the University of Pennsylvania's uterus transplant program, who was not part of the work in Brazil. The uterus is removed and immunosuppressants are stopped after birth, according to the Royal College of Obstetricians and Gynaecologists.

"There is always a potential risk for the one who gives the uterus".