It is something Ole Gunnar Solskjaer had the luxury of this week, with Manchester United returning from four days in Dubai on Thursday evening.
Guardiola also talked about the upcoming Premier League clash with Wolverhampton Wanderers and how the match is crucial to City's title credentials.
"When they can't be there it's hard", he said.
They have only one free weekend between now and the end of the season - February 17-18 - but that would have to stage an FA Cup fixture if they beat Burnley in the fourth round.
"Hopefully not, because that means we continue in the FA Cup and especially in the Champions League".
They took a significant step towards winning one of those trophies on Wednesday, thrashing third tier Burton Albion 9-0 in the first leg of their League Cup semi-final.
"We cannot substitute the mother and when the family can't be there, it's hard", said Guardiola.
Pep Guardiola has confirmed they are making good progress and could be in contention for a place in the side in Monday's crucial Premier League encounter.
He said: "Private lives can affect shorter and medium term performances a lot".
"They have to handle the situation and of course he is not alone, he has friends". "He is a little bit better, today was his first training session". He has incredible relationship with the Brazilian guys, like Danilo, Fernandinho, [and the Portuguese speaker] Bernardo [Silva], many, many players here. "Vincent [Kompany] is recovering well after the game against Liverpool".
Guardiola also claimed City will do everything they can to help Gabriel Jesus given the striker's family are travelling back to Brazil. "I think it won't be a problem for the next months".