In the absence of Cavani and Neymar, former United winger Angel Di Maria will be forced to step up on his first return to Old Trafford since moving to PSG in 2016 for £44.3m. Kimpembe, booked early on, might have been shown a second yellow on a couple of occasions before scoring the game's opener.
"United still have four of their five main rivals to play before the end of the season, starting with Liverpool at home a week on Sunday", Redknapp told the Daily Mail.
With a two-goal and one-man advantage, PSG were happy to stroke the ball around in the closing stages, their fans greeting every pass with cries of "Olé". Mbappe could have put the tie to bed shortly afterwards, but David de Gea did well to stand tall and deny Mbappe a second goal.
Check out 90min's breakdown of the game below.
Defence is the area where I think United need to improve the most, especially at centre-back which is where they still look vulnerable. However, the tempo of their play dropped significantly following the restart and they were deservedly punished.
'Yes. I've been disappointed quite a lot here [at Old Trafford] over the years but I wasn't disappointed tonight because they played against a team who played a fantastic match.
Despite the introduction of Romelu Lukaku, alongside the likes of Paul Pogba, Alexis Sanchez and Juan Mata, the home side were toothless in the final third as they tried to claw their way back into the game having fallen behind.
It made a bad situation worse for United since he will now miss the second leg due to suspension.
With Paul Pogba suspended it is going to be a very tough ask for them to make progress, even if Anthony Martial and Jesse Lingard are fit.
"And the whole evening Man United was dominated in midfield". If anyone deserves credit, it is Nemanja Matic for the way he stifled Julian Draxler by breaking up PSG attacks time and again during the first half.
'And then obviously the two goals.
By virtue of a superb second half showing, PSG earned their first win against an English side in Europe since beating Chelsea 2-1 in March 2014.
Tuchel's selection problems mirror PSG's first Champions League group game at Anfield, in which PSG could select only one recognised midfielder and were flattered by the scoreline in a 3-2 defeat.
Substitutes: Paredes (6), Dagba (6).
Marquinhos was excellent for the men from the French capital against United.
United have an opportunity to extend their pursuit of a 13th FA Cup success when they head for Stamford Bridge, where they were denied a league victory by Ross Barkley's late equaliser in October.
Meanwhile, PSG president Nasser Al-Khelaifi heaped praise on the Ligue 1 champions.